Figure 6.
A model describing some of the features of the homeostasis of Treg. In the steady state, tissue self-Ag, originated from dying cells, molecule shedding, or direct capture from live cells, are presented by Ag-presenting cells in draining LNs. This presentation of self-Ag induces activation of specific autoreactive cells derived from the pool of long-life resting Treg. During rapid expansion, the cells enter the pool of activated Treg, displaying an activated phenotype. Then, some of them die or recirculate in the spleen.