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. 2003 Nov 24;163(4):871–878. doi: 10.1083/jcb.200304132

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — Intravenously injected antinucleolin antibody accumulates in tumor blood vessels. An affinity-purified rabbit antinucleolin antibody (NCL3) was injected into the tail vein of mice bearing MDA-MB-435 xenograft tumors. The tumor and various organs were removed 1 h after the injection, sectioned, and examined for the presence of rabbit IgG using Alexa-594 anti–rabbit IgG (red). Blood vessels were stained with anti-CD31 antibody (green), and nuclei were counterstained with DAPI (blue). The antinucleolin antibody has bound to tumor blood vessels (a and b), but is not seen in the skin (c). Rabbit IgG injected similarly as a control does not bind to tumor blood vessels (d).

	
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