Table I. Comparison of the inhibitory patterns of the α-factor and amiodarone effects.
| Inhibition of death program caused by
|
||||
|---|---|---|---|---|
| Inhibitor of the death program | Target | α-factor | amiodarone | |
| Δste20 | Ste20 | + | − | |
| cycloheximide | translation | + | − | |
| rho 0 mutation | mtDNA | + | + | |
| Δcyc3 | cytochromes c | + | + | |
| myxothiazol | Qo center | + | + | |
| antimycin A | Qi center | − | − | |
| KCN | Cyt. ox. | + | + | |
| oligomycin | F0 | + | + | |
| FCCP (0.4 μM) | ΔΨm | + | + | |
| FCCP (6 μM) | ΔΨm | − | − | |
| C-PTIO | NO↓ | ND | − | |
| SNP | NO↑ | ND | + | |
| NAC | ROS↓ | + | + | |
| α-tocopherol | ROS↓ | + | + | |
| Δysp1 | Ysp1 | + | + | |
| Stimulation of death program caused by | ||||
| Activator of the death program | Target | α-factor | amiodarone | |
| Δcmd 1–6 | calmodulin-calcineurin system | + | + | |