Figure 7.
Effects of 7-day repeated treatment with vehicle (veh, 10% DMSO in 0.9% NaCl, s.c.), URB597 (3 mg kg−1 s.c.), OL-135 (3 mg kg−1 s.c.) or AA-5-HT (5 mg kg−1 s.c.) on mechanical withdrawal threshold (a) and thermal withdrawal latency (b) in sham and CCI rats. (c and d) The effects in sham and CCI rats of 3-day repeated treatment with vehicle (veh, 10% DMSO in 0.9% NaCl, s.c.), URB597 (3 mg kg−1 s.c.), OL135 (3 mg kg−1 s.c.) or AA-5-HT (5 mg kg−1 s.c.) on mechanical withdrawal threshold and thermal withdrawal latency, respectively. Each point represents the mean±s.e.m. of 10 animals per group. (*) Indicates significant differences vs sham/veh, (°) significant differences vs CCI/veh. P-values <0.05 were considered statistically significant.