Figure 4.
Summary of the drug resistance alleles detected. Results are shown for PR (top two grids) and RT (bottom two grids). The seven HIV samples studied are labeled to the left of each grid. The amino acid positions of drug-resistant mutations are marked at the top of the grid, labeled DRM for drug resistance mutation. Black tiles in the grid indicate positions that were significantly enriched for drug resistance mutations in the pyrosequencing data after correction for multiple comparisons. Raw counts are available in Supplementary Table 2. Black tiles with asterisks indicate positions that were enriched in drug resistance mutations in the pyrosequencing data that were not identified by a conventional genotyping method (Viroseq HIV Genotyping System v 2.0). The ‘i’ at RT position 69 denotes the insertions at this position that are known to confer drug resistance.