Fig. 3.
Coupled reaction sets involving cholesterol biosynthesis and glutathione production and transport. (A) The cholesterol biosynthesis coupled set includes all reactions except those shaded in gray. Note that the groups of reactions are not all directly connected and could not be identified by visual inspection alone. (B) Reactions in the glutathione reaction set were mapped to disease associations by using Mendelian Inheritance in Man identification tags. Deficiencies in glutathione synthetase (GTHS) or glutamate-cysteine ligase (GLUCYS) both result in hemolytic anemia, supporting the notion that enzyme deficiencies in the same coupled set may have similar phenotypes. Interference with or decreases in GLUCYS activity is associated with an increased risk of myocardial infarctions (MI). A high-resolution version of this figure is available in SI Figs. 19 and 20.