FIGURE 2.
PrMPs induce NO overproduction and iNOS expression in vessels. A: Concentration-effect curves of 5-HT in the presence (○) and in the absence (□) of L-NA (100 μmol/L) in mouse aortas incubated with CMPs for 24 hours (range, 3 to 17 nmol/L Eq PS; n = 9). B: Concentration-effect curves of 5-HT after 24 hours of preincubation with PrMP mouse aortas (range, 6 to 22 nmol/L Eq PS; n = 9) in the presence (•) and in the absence (▪) of L-NA (100 μmol/L). C: Quantification of the amplitude of NO-Fe(DETC)2 signal in unit/weight (mg of the dried sample A/W(ds), n = 8) in mouse aortas after incubation with either CMPs or PrMPs and exposed to 5-HT (10 μmol/L). D–F: Immunohistochemical staining of inducible NO synthase for mouse aorta after incubation with either medium without MPs, medium containing CMPs, or medium containing PrMPs, respectively.