Fig. 8. Intra- and intermolecular contacts of the TGEV Mpro N-terminus. (A) MOLSCRIPT stereo representation of a TGEV Mpro dimer. Molecule A is coloured from blue at the N-terminus, via green (domain II), to red (C-terminus), while molecule B is shown in grey. The catalytic Cys144 and His41 residues are labelled in both monomers. (B) Detailed view of the interactions made by the N-terminal segment (blue) and domains II/III of monomer A as well as domains II/III of monomer B. Residues critically involved in these interactions are designated by the single-letter code and shown in ball-and-stick representation (see text for details). The N- and C-termini of molecule A are indicated.