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IFN-α-treated Huh.BB7 cells yield edited replicon RNA. Four regions within the HCV IRES of BB7 replicon that contain mutations are shown. The wild-type BB7 sequences are shown. The nucleotides in the wild-type BB7 sequence that were mutated are shown in bold type and underlined, and the nucleotides obtained after IFN-α treatment are shown below the sequence.
